Sclareol is a labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13.
How much products actually contain
No product states its amount yet.
Of the products containing it, 1 list it before the 1% line and 3 after it (usually 1% or less).
Products using this ingredient
4 of 4 confirmed · likeliest to carry enough first
Definition
Sclareol is a labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13. It has been isolated from Salvia sclarea. It has a role as an antimicrobial agent, an antifungal agent, a fragrance, an apoptosis inducer and a plant metabolite.
Source: PubChem
US FDA substance register · UNII B607NP0Q8Y · registered name SCLAREOL · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- International fragrance standard (IFRA)
Source: EU Cosmetics Regulation · IFRA fragrance standards · MFDS (Korea) cosmetic regulatory information
European Union
- Other : The presence of the substance shall be indicated in the list of ingredients referred to in Article 19(1), point (g), when its concentration exceeds: — 0,001 % in leave-on products — 0,01 % in rinse-off products.
Source: MFDS (Korea) cosmetic regulatory information
EU Cosmetics Regulation, Annex III (restricted substances), entry 342
Restriction III/342
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name スクラレオール: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 515-03-7
- EC No.EU chemical inventory number
- 208-194-0
- DTXSIDUS EPA chemical ID
- DTXSID0047111
- DTXCIDUS EPA compound ID
- DTXCID8027111
- IUPAC
- (1R,2R,4aS,8aS)-1-[(3R)-3-Hydroxy-3-methylpent-4-en-1-yl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol
- Molecular formula
- C20H36O2
- Molecular weight
- 308.506 g/mol
Measured properties
- Appearance
- Large Crystals · Solid, Bitter herbaceous hay-like aroma
- Solubility
- Practically insoluble or insoluble in water · Soluble (in ethanol)
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance2
- Flavouring and nutrient2
- Intermediate2
Source: US EPA CompTox dashboard
Related literature
- Investigating the Endocrine Disruption Potential of Sclareol through Docking and Molecular Dynamics Simulation Methods · 2025
- Biotransformation of tobacco-derived Z-abienol into precursors of ambrox by newly identified Acinetobacter tjernbergiae LSC-2 · 2025
- Determination of The Essential Oil Components of Some Sage (Salvia Sp.) Species Naturally Distributed in The Isparta Province · 2023
- Transdermal Absorption of Sclareol, an Active Ingredient in Clary Sage Oil: A Complementary and Alternative Medicine for Menopausal Symptoms · 2022
- Sclareol attenuates the development of atopic dermatitis induced by 2,4-dinitrochlorobenzene in mice · 2019
Linked databases 22
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- EU SCCS safety opinions
- IFRA fragrance standards
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese