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Ingredient Dictionary

SQUALANE

Clinical evidence
  • Dryness C
Amount studies used
1–10%
When
morning and evening
Irritation
low

Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.

Molecular structure

How much products actually contain

18 products state the amountmedian 3%94% at or above the amount studies used (1–10%)

  • under 0.01% 1
  • 0.01–0.1% 0
  • 0.1–1% 0
  • 1% or more 17

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

Of the products containing it, 1,646 list it before the 1% line and 685 after it (usually 1% or less).

Where no amount is stated, a product listing it early reaches the study amount about 86% of the time, one listing it late about 5%.

Clinical evidence grade by skin concern

C
uncontrolled or multi-ingredient studies

Products using this ingredient

12 of 2,276 confirmed · likeliest to carry enough first · See all 2,276

Definition

US FDA substance register · UNII GW89575KF9 · registered name Squalane · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONINGReplaces oils washed awayREFATTINGSoftens hairHAIR CONDITIONINGMakes skin soft and smoothSKIN CONDITIONING - EMOLLIENT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Squalane and Squalene

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessment - 2001/2002

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of Squalane and Squalene

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name スクワラン: 本品は、次の化学式で表されるスクワレン（＊）の水素添加によって得られる飽和分岐鎖炭化水素である。

Source: JCIA labelling names (Japan)

Names & identifiers

SQUALANEINCI스쿠알란Korean label name (MFDS standard)Tetracosane, 2,6,10,15,19,23-hexamethyl-SynonymスクワランJapanese labelling name
CAS No.chemical registry number
111-01-3
EC No.EU chemical inventory number
203-825-6
DTXSIDUS EPA chemical ID
DTXSID0046513
DTXCIDUS EPA compound ID
DTXCID8026513
IUPAC
2,6,10,15,19,23-Hexamethyltetracosane
Molecular formula
C30H62
Molecular weight
422.826 g/mol

Measured properties

Appearance
Liquid · Liquid, [Merck Index] Colorless viscous liquid, [Sigma-Aldrich MSDS]
Boiling point
350 °C @760 [mm Hg]
Density
0.8115 @ 15°C
Colour
colourless
Melting/freezing point
-38 ℃
Initial boiling point and range
350 ℃
Flash point
217 ℃((c.c.))
Vapour pressure
10 ㎜Hg ((263 ℃))
Relative density
(0.8172)
Viscosity
31.12 cP (25 C)
Molecular weight
422.82

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 27 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Softener and conditioner22
  • Biocide2
  • Elasticizer2
  • Humectant1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 2 eye studies are on record.

Classed as moderate1Classed as low3

The studies disagree (the most common conclusion covers 25%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies
  • Not likely to be sensitizing
    skin sensitisation: in vivo (LLNA) · Screening · according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
  • SkinIrr2
    Skin Irritation · QSAR Predicted
  • Moderate or Mild Irritation
    skin irritation: in vivo · Screening · other guideline: Draize test according to
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · EPA OPPTS 870.2500 (Acute Dermal Irritation) according to
  • Not likely to be sensitizing
    skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
  • Moderate or Mild Irritation
    eye irritation: in vivo · Screening · other guideline: Draize Method according to
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · EPA OPPTS 870.2400 (Acute Eye Irritation) according to

Source: US EPA CompTox dashboard

Related literature

Linked databases 20

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