Tranexamic acid is a monocarboxylic acid.
- Dark spots B+
- Amount studies used
- 2–5%
- When
- morning and evening
- Irritation
- low
Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.
How much products actually contain
38 products state the amountmedian 3%79% at or above the amount studies used (2–5%)
- under 0.01% 2
- 0.01–0.1% 3
- 0.1–1% 2
- 1% or more 31
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 185 list it before the 1% line and 124 after it (usually 1% or less).
Where no amount is stated, a product listing it early reaches the study amount about 84% of the time, one listing it late about 3%.
Clinical evidence grade by skin concern
- B
- one or two randomised trials
Products using this ingredient
12 of 308 confirmed · likeliest to carry enough first · See all 308
Cos De BAHAT15 Serum15% stated · study amount
Cos De BAHATT Serum10% stated · study amount
CNP LaboratoryDerma Answer Brightening Booster TXA-PDRN Ampule10% stated · study amount
CNP LaboratoryDerma Answer Brightening Booster TXA-PDRN Ampule10% stated · study amount
GoodalGreen Tangerine Vita C E TXA Serum 30ml6% stated · study amount
Cos De BAHATN Serum5% stated · study amount
Biome ActivateTranexamic Acid Cream5% stated · study amount
WISELYNiacin-Tranexamic Marks Serum5% stated · study amount
medicubemedicube TXA Toning Serum5% stated · study amount
AnuaTXA Niacin Dark Spot Serum 30ml 2-Pack4% stated · study amount
Haruharu WonderHaruharu Wonder 4% TXA Gel Serum / Unscented4% stated · study amount
SidmoolSkin Source Ultra Albutin Cream4% stated · study amount
Definition
Tranexamic acid is a monocarboxylic acid. It has a role as an antifibrinolytic drug and a hematologic agent. It is functionally related to a cyclohexanecarboxylic acid.
Source: PubChem
US FDA substance register · UNII 6T84R30KC1 · registered name Tranexamic acid · single chemical substance
Cosmetic roles
Safety & regulatory references
ASEAN
- Field of application and/or use : Skin products
- Maximum authorised concentration in the finished cosmetic product : 3.0%
- Other limitations and requirements : Not to be used in products intended to be placed in contact with mucous membranes
Taiwan
- Maximum concentration : 3%
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 1197-18-8
- CAS No.chemical registry number
- 701-54-2
- EC No.EU chemical inventory number
- 214-818-2
- DTXSIDUS EPA chemical ID
- DTXSID3045350
- DTXCIDUS EPA compound ID
- DTXCID401333941
- IUPAC
- (1r,4r)-4-(Aminomethyl)cyclohexane-1-carboxylic acid
- Molecular formula
- C8H15NO2
- Molecular weight
- 157.213 g/mol
Measured properties
- Melting point
- >300 °C
- Appearance
- solid
- Colour
- white
- Odour
- odourless
- Melting/freezing point
- &, gt, 300 ℃
- Water solubility
- 167000 ㎎/ℓ
- n-Octanol/water partition coefficient (Kow)
- -1.900
- Molecular weight
- 157.21
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 7 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Astringent (EPA)3
- Softener and conditioner3
- Pharmaceutical (EPA)1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- SkinIrr2
Skin Irritation · QSAR Predicted - Category 6.3B (Category 3)
Skin Irritation · Read Across - SkinSens1
Skin Sensitization · QSAR Predicted - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- THE USE OF TRANEXAMIC ACID IN DERMATOLOGY · 2023
- The uses of tranexamic acid in dermatology: a review · 2022
- Combination of Oral Tranexamic Acid with Topical 3% Tranexamic Acid versus Oral Tranexamic Acid with Topical 20% Azelaic Acid in the Treatment of Melasma. · 2019
- Comparative study between topical tranexamic acid and intradermal tranexamic acid injection in treatment of melasma · 2019
- Safety and Efficacy Profile of Oral Tranexamic Acid v/s Tranexamic Acid Soaks v/s Tranexamic Acid Cream in Treatment of Melasma – A Hospital Based Prospective Randomised Controlled Comparative Study · 2018
Linked databases 21
- ASEAN Cosmetic Directive
- ChEBI
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Taiwan FDA cosmetic regulations
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese